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20th International Conference on Metabolomics & Systems Biology, will be organized around the theme “”
Eurometabolomics-2024 is comprised of keynote and speakers sessions on latest cutting edge research designed to offer comprehensive global discussions that address current issues in Eurometabolomics-2024
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Metabolomics is the large-scale study of small molecules, commonly known as metabolites, within cells, biofluids, tissues or organisms. Collectively, these small molecules and their interactions within a biological system are known as the metabolome.
Systems biology is an approach in biomedical research to understanding the larger picture be it at the level of the organism, tissue, or cell—by putting its pieces together. It's in stark contrast to decades of reductionist biology, which involves taking the pieces apart.
Changes in plant metabolism are at the heart of plant developmental processes, underpinning many of the ways in which plants respond to the environment. As such, the comprehensive study of plant metabolism, or metabolomics, is highly valuable in identifying phenotypic effects of abiotic and biotic stresses on plants.
NMR-based metabolomics provides a means to categorize organ-specific toxicity, monitor the onset and progression of toxicological effects, and identify biomarkers of toxicity. A future challenge, however, is to describe the cellular metabolome for purposes of understanding cellular functions
Mass spectrometry-based metabolomics offers quantitative analyses with high selectivity and sensitivity and the potential to identify metabolites. Mass spectrometry-based metabolomics approaches can enable detection and quantification of many thousands of metabolite features simultaneously. However, compound identification and reliable quantification are greatly complicated owing to the chemical complexity and dynamic range of the metabolome.
The two most common analytical approaches for the generation of metabolomics data are nuclear magnetic resonance (NMR) spectroscopy and mass spectrometry (MS). NMR is a spectroscopic technique based on the principle of energy absorption and re-emission of the atom nuclei due to variations in an external magnetic field.
Two main analytical techniques are currently being used in metabolomics: nuclear magnetic resonance (NMR) spectroscopy and high-resolution mass spectrometry (HRMS). Modern separation techniques, such as liquid chromatography (LC), gas chromatography (GC), or capillary electrophoresis (CE), are often coupled with HRMS.
At present, metabolomics is applied to investigate several human diseases, to improve their diagnosis and prevention, and to design better therapeutic strategies. In addition, metabolomic studies are also being carried out in areas such as toxicology and pharmacology, crop breeding, and plant biotechnology.
Metabolomics cancer research is being used to discover diagnostic cancer biomarkers in the clinic and in a research institute, to a better understand its complex heterogeneous nature, to discover pathways which involved in cancer that could be used for new targets and to monitor metabolic biomarkers during therapeutic intervention. These metabolomics approaches may also provide evidence to personalized cancer treatments by providing useful information to the clinician about the cancer patient’s response to medical interventions. The ultimate aims of most metabolomics cancer studies are to discover cancer-specific diagnostic, prognostic or predictive biomarkers for a patient. Untargeted metabolomics is an important and excellent tool for probing cancer-altered biochemical pathways.
Metabolomics is an emerging analytical technique for systemic determination of metabolite profiles, which is useful for understanding the biochemical changes in related diseases. It is increasingly being applied towards the identification of biomarkers for disease diagnosis and risk prediction
Proteomics is the study of proteomes on a vast scale. A proteome is a collection of proteins made by a living creature, system, or biological milieu. We can talk about a species' proteome (for example, Homo sapiens) or an organ's proteome (for example, the liver). The proteome is dynamic, varying from cell to cell and changing throughout time. The proteome reflects the underlying transcriptome to some extent. However, in addition to the expression level of the relevant gene, many other factors influence protein activity (which is generally measured by the response rate of the processes in which the protein is engaged).
The structure, function, evolution, mapping, and editing of genomes are all studied in genomics, which is an interdisciplinary subject of biology. A genome is a full set of DNA that includes all of an organism's genes. In contrast to genetics, which focuses on individual genes and their functions in inheritance, genomics tries to characterise and quantify all of an organism's genes, as well as their interrelationships and effects on the organism as a whole. With the help of enzymes and messenger molecules, genes may direct the production of proteins. Proteins, in turn, are responsible for the formation of body structures such as organs and tissues, as well as the management of chemical reactions and the transmission of information between cells. Genomics also entails the assembly and analysis of complete genomes using high-throughput DNA sequencing and bioinformatics to assemble and study their function and structure. Advances in genomes have sparked a revolution in discovery-based research and systems biology, making even the most complicated biological systems like the brain easier to comprehend.