Metabolomics & Systems Biology

Vladimir Tolstikov, Ph.D., is Director of Metabolomics at BERG. He received B.S. and M.S in Organic Chemistry in 1977 from M.V. Lomonosov Institute of Fine Chemical Technology, in Moscow, Russia. He received Ph.D. in Organic Chemistry in 1983 from the Institute of Chemical Means for Plant Protection, Moscow, Russia. He is a pioneer in HILIC separations development applied to Metabolomics. During his career he was working in leading research institutions in USA, Germany, Hungary and Russian Federation. He has joined Eli Lilly and Company in 2012. He is author contributor and participant of 45 conferences, 5 book chapters, and 54 articles

Metabolomics, Systems Biology

Mishra received his B. S (Honors) and M.S degrees from Patna University ( then nicknamed as Oxford of the East) in India and Ph. D Degree from McMaster University. He received his post –doctoral training with the late Nobel Laureate Professor E. L. Tatum at the Rockefeller University. He was a Fellow for Medical Research of the Jane Coffin Child Fund of the Yale University at the Rockefeller University for two years and then Research Associate with Professor Tatum where he initiated his work in what is now called as Proteomics and Matabolomics.

Biological Sciences

Narendra Yadav Demonstrated success in biotechnology, including two once-in-a-lifetime breakthroughs: 1) Discovered omega 6 desaturase gene that led to the biotech soybean oil Plenish® benefitting farmers (anticipated to be the 4th largest U.S. row crop by 2023), the food industry, and consumers with its zero trans fat oil (“In a Bean, a Boon to Biotech”, New York Times, Nov 15, 2013).2) Engineered yeast into the richest source of omega-3 fatty acids, described by Nature Biotechnology as a ‘metabolic-engineering tour de force’. Its use in VerlassoTM salmon replaced 75% of the wild-caught fish needed in aquaculture to earn the distinction of “better alternative” by Seafood Watch. Inventor on 63 granted patents.  Author on 23 peer-reviewed papers in high impact journals.  Successful metabolic engineering of one plant and two microbes from start to finish and all worked!  Genetically engineered both central and secondary metabolic pathways in plants and microbes.  Genome editing in plants and microbes as well as in their organelles (mitochondria and chloroplasts).  Demonstrated expertise in bioinformatics, gene discovery, cutting edge DNA assembly.  high throughput, automated microbe engineering using Benchling platform and robots, such as Mantis, Bravo, Guava, Tecan, and Fragment Analyzer.

Synthetic Biology

Dr. Bryan earned his undergraduate Bachelor of Science degree in Biochemistry from the University of Texas at Austin and his doctoral degree from Louisiana State University School of Medicine in Shreveport where he was the recipient of the Dean’s Award for Excellence in Research. He pursued his post-doctoral training as a Kirschstein Fellow at Boston University School of Medicine in the Whitaker Cardiovascular Institute. After a two year post-doctoral fellowship, in 2006 Dr. Bryan was recruited to join faculty at the University of Texas Health Science Center at Houston by Ferid Murad, M.D., Ph.D., 1998 Nobel Laureate in Medicine or Physiology. During his tenure as faculty and independent investigator at UT, his research focused on drug discovery through screening natural product libraries for active compounds. His nine years at UT led to several discoveries which have resulted in eight issued US and international patents and nine pending worldwide. Specifically, Dr. Bryan was the first to describe nitrite and nitrate as indispensable nutrients required for optimal cardiovascular health. He was the first to demonstrate and discover an endocrine function of nitric oxide via the formation of S-nitrosoglutathione and inorganic nitrite. Through the drug discovery program in natural product chemistry, Dr. Bryan discovered unique compositions of matter than can be used to safely and effectively generate and restore nitric oxide in humans. This technology is now validated in six published clinical trials and Dr. Bryan has 9 issued US and International patents. He is also a successful entrepreneur who has successfully commercialized his nitric oxide technology through a UT portfolio company, named to the Inc 5000 fastest growing companies in the US for the past 3 years straight. Dr. Bryan has been involved in nitric oxide research for the past 16 years and has made many seminal discoveries in the field. These discoveries and findings have transformed the development of safe and effective functional bioactive natural products in the treatment and prevention of human disease and may provide the basis for new preventive or therapeutic strategies in many chronic diseases. Dr. Bryan has published a number of highly cited papers and authored or edited 5 books. He is an international leader in molecular medicine and nitric oxide biochemistry.

Biochemistry

Gerald C. Hsu received an honorable PhD in mathematics and majored in engineering at MIT. He attended different universities over 17 years and studied seven academic disciplines. He has spent 20,000 hours in T2D research. First, he studied six metabolic diseases and food nutrition during 2010-2013, then conducted research during 2014-2018. His approach is “math-physics and quantitative medicine” based on mathematics, physics, engineering modeling, signal processing, computer science, big data analytics, statistics, machine learning, and AI. His main focus is on preventive medicine using prediction tools. He believes that the better the prediction, the more control you have.

Preventive medicine using prediction tools

Boris Zaslavsky graduated in Analytical Chemistry from the Moscow State University. He holds a PhD and a DSc (USSR Academy of Sciences), was a scientist at USSR Academy of Sciences (1971-1991), Visiting Fellow at Cornell University Medical School (NYC, 1991-1992), and KV Pharmaceuticals (1993-1994), Argonne National Laboratory (1994-1995). He is the founder of Analiza, Inc. (1996-present) and Cleveland Diagnostics (2014-present), where serves as a Chief Scientific Officer. He published 1 monograph, over 120 scientific papers, and 7 patents. His research interests are development of analytical applications of aqueous two-phase partitioning, new clinical tests for early cancer detection and other applications, role of water in biology, and protein-water interactions.

Systems Biology

Xuanxian Peng is a Professor, School of Life Sciences, Sun Yat-Sen University, China. He received his Ph.D. from Xiamen University, China and studied at McGill University, Canada as a postdoctoral fellow. Professor Peng was the first Dean of School of Life Sciences, Xiamen University, China from 1999 to 2003. He was a member of the fifth Chinese Education Ministry for Sciences and Technology and vice chairmen of Chinese Society for Marine Biochemistry and Molecular Biology. His research focuses on functional metabolomics for antibiotic resistance, which have recently been published in Cell Metabolism and PNAS

Functional metabolomics for antibiotic resistance

Dr Ivan Minic, student of Academic Doctoral studies, Dental science, department of Oral medicine and Parodontology, Medical faculty, University of Nis, Serbia. I participated in several international congresses, the author of more than 25 scientific papers, a member of the editorial board of over 30 journals and reviews over 15 journals.

Dr Ivan Minic is interested in Oral medicine, Parodontology, Oral parology, drug investigation, biomedical science, metabolic disease.

Petra Perner is the founder and director of the Institute of Computer Vision and Applied Computer Sciences in Leipzig, Germany. Under her leadership the institute developed to one of the leading institutes in basic and applied research in computer vision, data mining, machine learning, case-based reasoning and image databases. She received a diploma degree in electrical engineering in 1981 and a PhD degree in computer science in 1985. In 1989 she finished her habilitation entitled “A Methodology for the Development of Knowledge-Based Image-Interpretation Systems”. Under her guidance highly qualified national and international personnel got trained in the above mentioned high-technology fields through research projects and education programs. The tutorial on Data Mining (www.data-mining-tutorial.de) is a recognized tutorial among the domain experts and is especially designed for training industrial people on hot topics in data mining. She gave courses on Data Mining and Image Interpretation at different universities in various countries. She has been the project leader and principal investigator of various national and international research projects for which she received several research awards. Her projects are marked by the fact that they tie together high-class research with the aspect of the economic application. She is frequently invited as a guest professor for knowledge-based image inspection systems by several national and international institutes and companies. She supervised the foundation of two high-technology companies named ibai-solutions (www.ibai-solutions.de) and ImageInterpret GmbH (www.imageinterpret.de) whose teams received 4 distinct business prices for transferring image-interpretation and data-mining methods to industry. She was the principal founder and chairwoman of the Technical Committee “Machine Learning and Data Mining”. She is the chairwoman of three distinct conferences in Machine Learning, Data Mining and High-Content Analysis of Signals and Images called MLDM (www.mldm.de), ICDM (www.data-mining.forum.de) and MDA (www.mda-signals.de). Presently she is working on various medical, chemical and biomedical applications, information management applications, technical diagnosis and e-commerce applications. Most of the developments are protected by legal patent rights and can be licenced to qualified industries. She has published numerous scientific publications and patents and is frequently requested as pleanary speaker in distinct research fields as well as across disciplinces. Her vision is to build intelligent flexible and robust data-interpreting systems that are inspired by the human case-based reasoning process.

Research Interest Applied Computer Science, Data Mining

Prof. Xia is the Dean of the School of Public Health, Nanjing Medical University, Vice Director of Center for Global Health and the PI of State Key Laboratory of Reproductive Medicine and Key Laboratory of Modern Toxicology of the Ministry of Education. His current research interests are Systems Biology and Environmental Health. He has been using high-throughput techniques to profile human environmental exposure and biological responses to exogenous chemicals. Prof. Xia has presided over more than ten national and ministerial projects, including the State Key Program of National Natural Science Foundation of China and the National Outstanding Youth Science Foundation. He has been the Committee Member of several domestic and international academic organizations. Prof. Xia has published over 110 peer-reviewed articles, and got 7 national invention patents. He also serves as the editor and reviewer of more than 20 international journals.

Systems Biology and Environmental Health.

Hui Li is a Professor, School of Life Sciences, Sun Yat-Sen University, China. She received her Ph.D. from Sichuan University, China and studied at Sun Yat-sen University,China as a postdoctoral fellow. Her research focuses on functional metabolomics for antibiotic resistance, which have recently been published in Cell Metabolism and PNAS

Functional metabolomics for antibiotic resistance

Bo Peng has his expertise in metabolic regulation of antibiotic resistance. His research focuses on the elucidation of the metabolic features antibiotic-resistant bacteria He proposed that antibiotic-resistant bacteria have their metabolomes, naming antibiotic-resistance metabolome (ARM). The crucial biomarkers identified from ARM could reverts the ARM to antibiotic-sensitive metabolome (ASM), which increase the killing efficacy of antibiotics to multidrug-resistant bacteria, biofilm-forming bacteria and persisters (Peng et al, Cell metabolism, 2015). This strategy is also applicable to enhance host immune response to infections through metabolic regulations. Thus, this approach provides a novel strategy to fight against antibiotic-resistant bacteria in a greener but efficient way.

Elucidation of the metabolic features antibiotic-resistant bacteria

Leads scientific laboratory using structural biology tools including NMR spectroscopy to discover protein ligands, functions and exploitation routes. Specialization in proteins involved in membrane recognition, genetic diseases, oncoproteins and microbial pathogenesis. Interests in drug discovery, membrane nanoparticles, and technologies for understanding and exploiting interactions of proteins and organelles.

Specialties: structural biology, NMR spectroscopy, drug discovery, cancer mechanisms, SME collaborations, industrial partnerships, scientific infrastructure, regional and city strategic development

Mishra received his post –doctoral training with the late Nobel Laureate Professor E. L. Tatum at the Rockefeller University and Ph. D Degree from McMaster University.He received his B. S and M.S degrees from Patna University ( then nicknamed as Oxford of the East) in India. Later he joined the University of South Carolina Molecular Biology Group and Chairman of the Microbiology dept in the Medical School and remained as Professor of Genetics in the Dept. of Biological Sciences. He was also a Visiting Professor at the Max Planck Institute for Molecular Biology in Heidelberg, Germany and in Genetic Institute of Greenwood, SC. In addition to a large number of articles published in leading journals, he has published two books by John Wiley & Sons of New York, one on Proteomics in 2010; this book has been endorsed by Nobel Laureate Professor Gunter Blobel. Dr Mishra is also on the Board of Journal, Proteomics & Bioinformatics.

Metabolomics & Proteomics

Boris Zaslavsky graduated in Analytical Chemistry from the Moscow State University. He holds a PhD and a DSc (USSR Academy of Sciences), was a scientist at USSR Academy of Sciences (1971-1991), Visiting Fellow at Cornell University Medical School (NYC, 1991-1992), and KV Pharmaceuticals (1993-1994), Argonne National Laboratory (1994-1995). He is the founder of Analiza, Inc. (1996-present) and Cleveland Diagnostics (2014-present), where serves as a Chief Scientific Officer. He published 1 monograph, over 120 scientific papers, and 7 patents. His research interests are development of analytical applications of aqueous two-phase partitioning, new clinical tests for early cancer detection and other applications, role of water in biology, and protein-water interactions.

Systems Biology

Petra Perner (IAPR Fellow) is the director of the Institute of Computer Vision and Applied Computer Sciences IBaI in Leipzig, Germany. She received her Diploma degree in electrical engineering and her PhD degree in computer science for the work on “Data Reduction Methods for Industrial Robots with Direct Teach-in-Programing”. Her habilitation thesis was about “A Methodology for the Development of Knowledge-Based Image-Interpretation Systems". She has been the principal investigator of various national and international research projects. She received several research awards for her research work and has been awarded with 3 business awards for her work on bringing intelligent image interpretation methods and data mining methods into business.

Computational Systems Biology

K. Ogata has completed his PhD at the age of 27 years from Yokohama City University in 1992 and postdoctoral studies from RIKEN tsukuba institute. In 1997, He became the leader of the regulation of protein function project, Kanagawa Academy of Science and Technology (KAST), and from 2001,the professor and chair person of Department of Biochemistry, Yokohama City University Graduate School of Medicine.He has published papers in JMB, PNAS, NSMB, and Cell, and had been serving as an editorial board member of BBRC (2009-2010)

Metabolomics

Tao Huang has been the Director of Bioinformatics Core Facility at Institute of Health Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences since 2014. From 2012 to 2014, he was a Postdoctoral Fellow at Department of Genetics and Genomics Sciences, Icahn School of Medicine at Mount Sinai, New York City, USA. His research interests include bioinformatics, computational biology, systems genetics and big data research. He has published over 100 articles in peer-reviewed journals. His works have been cited for 3138 times with an h-index of 26 and an i10-index of 64. He has been independent reviewer for about 30 journals. He is Editor for Book Computational Systems Biology - Methods and Protocols of Springer, Guest Editor for BBA Molecular Basis of Disease, BBA General Subjects, Artificial Intelligence in Medicine, BioMed Research International, Combinatorial Chemistry & High Throughput Screening and Computational and Mathematical Methods in Medicine.

Bioinformatics

Dr. Vladimir Bondarenko is Assistant Professor at Georgia State University, USA. He did his Ph.D. Physics and Mathematics, Moscow State University , Russia , 1990. Dr. Bondarenko's research interests include dynamical systems, neuronal and cardiac cell models, neural networks, models of cardiac arrhythmias, ion channel models.

Systems Biology