Metabolomics and Systems Biology

Statement of the Problem: Most young people are healthy, and with aging, they develop the degenerative diseases. In the last thirty years, it was thought that the disorders in aging are genetic and cannot be prevented. We present here the proof of concept that the aging-associated diseases are not genetic, but develops because of the chemically modified proteins. The discovery leads to effective prevention of the cell degeneration in aging and infection permitting to keep people healthy longer and improving the quality of life.

Methodology & Theoretical Orientation: The peptides corresponding to the intrinsically disordered sequences were synthesized in vitro and incubated with xanthurenic acid to obtain the covalently modified polymers observed on the SDSPAGE (patents). The polymers were injected into rabbits. The IgG's were isolated and tested in the primary cell cultures, in vivo in mice (outsourcing) and human, directly used by the investigator for her dermatitis and the metabolic disorder.

Findings: In a primary cell culture Xan led to the cell death caused by the covalently modified proteins. The regulatory sequences of the proteins, called intrinsically disordered sequences (IDSeqs) are preferentially modified. Any cell system cannot remove the chemically modified and polymerized IDSeqs. They alter the cell membranes leading to the caspases activation and cell degeneration.The author established a new technology targeting the chemically modified proteins. In mice, the molecule establishing membranes (MEMS) healed the Staphylococcus aureus and restored immunity in cyclophosphamide-treated mice using MEMS A-144 at five micrograms, weekly, on the mouth mucosa cured skin infection and cardiovascular disorder.

Conclusion & Significance: The chemically modified proteins must be eliminated to restore the cell homeostasis. MEMS stops the upstream cause of the pathology in infection or aging.